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The use of ILE for naproxen toxicosis | VETgirl Veterinary CE Podcasts

In today’s VETgirl online veterinary CE podcast, we review Herring et al’s recent publication in Journal of Veterinary Emergency Critical Care called “Intravenous lipid emulsion therapy in three cases of canine naproxen overdose.” Naproxen, an OTC or prescription human NSAID, has a narrow margin of safety in dogs and cats. As little as 5 mg/kg can result in gastrointestinal distress (e.g., vomiting, diarrhea, etc.) while doses > 10-25 mg/kg can result in acute kidney injury (AKI). Doses > 50 mg/kg can result in central nervous system signs (e.g., tremors, coma, etc.).

In this case series, Dr. Herring et al review 3 dogs that were successfully treated with intravenous lipid emulsion (ILE), along with standard treatment for NSAIDs. More importantly, this study looks at naproxen levels – both pre-ILE administration and 1,3 hours post-ILE administration, to provide evidence-based medicine that systemic naproxen levels decreased with ILE therapy. When in doubt, if you’re not sure how lipophilic the drug is or what the pKa is, contact the ASPCA Animal Poison Control Center for life-saving advice.

ASPCA logo Nov 2015

References:

1. Herring JM, McMichael MA, Corsi R, et al. Intravenous lipid emulsion therapy in three cases of canine naproxen overdose. J Vet Emerg Crit Care 2015;25(5):672-8.

 

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